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  • July 03, 2017. Health care system | definition of health care system by... (http://medical-dictionary.thefreedictionary.com/hea lth+care+system) Original Article. Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus. Kevan C. Herold, M.D., William Hagopian, M.D., Ph.D., Julie A. Auger, B.A., Ena...
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  • July 28, 2017. Insulin Needs after CD3-Antibody Therapy in New-Onset Type... (http://www.nejm.org/doi/full/10.1056/NEJMoa043980) Type 1 diabetes is a chronic illness characterized by the body’s inability to produce insulin due to the autoimmune destruction of the beta cells in the...
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  • August 24, 2017. Otelixizumab in the Treatment of Type 1 Diabetes Mellitus (http://www.medscape.com/viewarticle/754683_3) Immunotherapy trials in recent-onset type 1 diabetes (T1D) have had mixed results, with some therapies—anti-CD3 monoclonal antibodies targeting T cells (1–7...
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    Immune intervention with anti-CD3 in diabetes - Nature...
  • August 21, 2017. 053002 Anti-CD3 Monoclonal Antibody in New-Onset Type 1 (http://www.nejm.org/doi/pdf/10.1056/NEJMoa012864) Anti-CD3 monoclonal antibodies (MAbs) were developed as a way of inducing immune suppression of T cells. More recent studies have indicated that anti-CD3 MAbs can...
  • September 17, 2017

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    Targeting Memory T Cells in Type 1 Diabetes | SpringerLink
  • September 20, 2017. Progress Toward a Cure for Type I Diabetes: Research and... (https://www.niddk.nih.gov/about-niddk/budget-legisl ative-information/progress-toward-cure-type-1-diabe tes/Pages/default.aspx) Figure 1 Activity of Anti–Programmed Death 1 (PD-1) Antibody in Patients with Treatment-Refractory Melanoma, Non–Small-Cell Lung Cancer, or Renal-Cell Cancer.
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    Are Stem Cells the Next Frontier for diabetes treatment...
  • September 15, 2017. Are Stem Cells the Next Frontier for diabetes treatment... (https://stemcells.nih.gov/info/Regenerative_Medicin e/2006Chapter7.htm) CD Markers - CD3... B cells, histiocytes and histiocytic lesions, osteoblasts Most B cell lymphomas, but aberrant staining exists (Am J Surg Pathol 2012;36:1364
  • October 14, 2017

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    Digestive Disorders Center: Digestive Disorders Overview...
  • October 12, 2017. Pediatric Type 1 Diabetes Mellitus Workup: Approach... (http://emedicine.medscape.com/article/919999-workup) News and updates on potential cures for type-1 diabetes, that are in human (or clinical) trials. "In vitae veritate"
  • October 17, 2017

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    Can We Prevent Type 1 Diabetes? | SpringerLink
  • November 08, 2017

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    Anti-CD3 Antibody Treatment Induces Hypoglycemia and Super...
  • November 07, 2017. Immune therapy for type 1 diabetes mellitus—what is unique... (http://www.nature.com/nrendo/journal/v6/n3/full/nre ndo.2009.275.html) This is a randomized placebo controlled study to test whether a single 14 course of treatment with the anti-CD3 monoclonal antibody...
  • December 08, 2017

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    Diabetes: Anti-CD3 antibody therapy for type 1 diabetes mellitus...
  • December 10, 2017. Treatment of Type 1 diabetes with anti-CD3 monoclonal... - NCBI (https://www.ncbi.nlm.nih.gov/pubmed/14610290) Anti-CD3 monoclonal antibodies (MAbs) were developed as a way of inducing immune suppression of T cells. Preclinical data suggest that anti-CD3 MAb induces a population of regulatory T cells that can prevent or lead to reversal of Type 1 diabetes.
  • December 11, 2017

    Comments about this video:

    JCI - Immune therapy for treating type 1 diabetes: challenging...
  • December 12, 2017. Anti-CD3 therapy permits regulatory T cells to surmount T cell... (http://jem.rupress.org/content/207/9/1879) Aug 2, 2010 Treatment with anti-CD3 is a promising therapeutic approach for autoimmune diabetes, but its mechanism of action remains unclear. Foxp3+ regulatory T (T reg) cells may be involved, but the evidence has been conflicting. We investigated this issue in mice derived from the NOD model, which were .


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